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While full-length hGH activates growth hormone receptors causing multiple effects (growth promotion, insulin resistance, lipolysis), AOD9604 is studied for its receptor-independent actions on fat cells

demonstrated that a 5.6% weight loss in the group treated with liraglutide 1.8 mg/day compared with placebo was associated to reductions in both total fat and lean body mass measured by Dual-Energy X-ray Absorptiometry (DXA), as well as in visceral and subcutaneous adipose tissues measured by Magnetic Resonance Imaging (MRI) [54]

Importantly, both PXN HIGH and CAF HIGH were found to increase these neuromodulator levels in both age groups

Of more than 100 compounds synthesized and tested for TGR inhibition (a more thorough description of compound design will form the basis of a future manuscript), the most promising were selected to be extensively characterized in the in vitro and in vivo studies described below